Fig. 3

Overall point sensitivities of key UK service evaluations. SS-AN-PCR1: SS of the anterior nares using PCR. SS-AN-LFD1: SS of anterior nares using the Orient Gene LFD. SS-AN-LFD2: SS of anterior nares using the SureScreen LFD. SS-AN-LFD3: SS of anterior nares using the SureScreen LFD at participants’ home. SS-AN-LFD4: SS of anterior nares using the Innova LFD at participants’ home. SS-NT-LFD1, SS-NT-LFD2: SS of the nose and throat using the Innova LFD. SS-NT-LFD3: SS of the nose and throat using the Innova LFD at participants’ home. AS-NT-LFD1: AS of the nose and throat using the Innova LFD. AS-AN-LFD1: AS of nose and throat and anterior nares using the Orient Gene LFD. SS-MT-LFD1: SS of both nostrils to mid-turbinate level using the Innova LFD. AS-AN-LFD2: AS of anterior nares using Innova LFD. Sensitivity = TP/(TP + FN) based on corresponding qRT-PCR test results; binomial 95% CIs, Pearson-Klopper method. AN, anterior nares; AS, assisted swabbing; CI, confidence interval; FN, false negative; LFD, lateral flow device; MT, mid-turbinate level, NT, nose and throat; PCR, polymerase chain reaction; SS, self-swabbing; TP, true positive. The dotted vertical line indicates a diagnostic sensitivity of 50%, which was deemed sufficient in a real-world setting for use in the NHSTT program